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Similar LV reverse remodeling and LV reverse dyssynchrony demonstrated in cardiac resynchronization therapy by right ventricular apical and right ventricular high posterior septal More left ventricular reverse dyssynchrony is found in concordant left ventricular leads vs. discordant left ventricular leads.



Peak-stimulated growth hormone is positively associated with LDL and HDL particle size not VLDL particle size Multivariate regression analysis controlling for age, gender, race, ethnicity, tobacco, use of lipid-lowering medication, BMI and HOMA demonstrated peak-stimulated growth hormone remained significantly associated with LDL particle size and HDL particle size.



5-Fr sheaths reduce the rate of radial artery occlusion by as much as 55% PCI and left ventriculography are reported by more number of patients in the 6-Fr group than with the 5-Fr group.



Sex hormone-binding globulin levels are controlled by body composition but not vice versa Negative association is shown by weight, BMI, whole body fat mass and truncal fat mass with sex hormone-binding globulin levels.



Relationship between chronic hyperglycemia and subclinical myocardial injury There exists an association between elevated HbA1c and elevated high-sensitivity cardiac troponin T among people without clinically evident coronary heart disease



Association between masked hypertension, endothelial dysfunction, and arterial stiffness in patients with T2DM There is a significant association of daytime systolic BP (ABPM), estimated duration of diabetes and serum triglycerides with FMD and daytime systolic BP(ABPM)



The MYTHOS (Induced Diuresis with Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) Trial: significantly reduced risk of Contrast Induced Nephropathy by furosemide with matched hydration A lower incidence of cumulative in-hospital clinical complications is observed in furosemide-treated patients than in controls



Possible occurrence of systemic inflammatory response syndrome after TAVI is a strong predictor of mortality Major vascular complications and the number of ventricular pacing runs are the independent predictors of systemic inflammatory response syndrome.



Association between resting heart rate and mortality in T2DM patients Association between increased risk and a higher baseline resting heart rate is most pronounced among patients with previous macrovascular complications



j-Cypher Registry: Very late adverse events with implantation of Sirolimus-Eluting Stents Based on the timing of stent thrombosis onset, completely different independent risk factors of ST are identified in the patient population



Parasternal approach for evaluation of morphology of atrial septal defect for transcatheter closure using two- and three-dimensional transthoracic echocardiography Three-dimensional transthoracic echocardiography from the right parasternal approach improves visualization of the shape and location of atrial septal defects from 65.5% to 74.5%



Association of orthostatic hypotension with nocturnal change in systolic blood pressure Orthostatic hypotension is associated with nocturnal change in systolic blood pressure



Clinical outcomes in patients with critical limb ischemia on statins Patients with critical limb ischemia who take periprocedural statins have improved outcomes at 2 years after endovascular treatment



Effects of ursodeoxycholic acid on endothelial function and inflammatory markers in patients with chronic heart failure UDCA improved liver function, in terms of lowering γ-glutamyl transferase, aspartate transaminase, and soluble tumor necrosis factor α receptor 1, compared to placebo



Long-term prognostic impact of myocardial infarction on cardiovascular mortality in patients with non-ST-elevation acute coronary syndrome There is a substantial increase in long-term mortality after a spontaneous MI



Impact of type 2 diabetes mellitus (DM) on postoperative bioprosthetic structural valve degeneration Type 2 DM is associated with faster degeneration of bioprosthetic valve



REVERSE trial: effects of the left and right ventricular lead tip position in response to cardiac resynchronization therapy The proportion of worsened HF clinical composite response uncorrelated with lead position, whereas the non-apical in comparison with the apical LV lead positions showed a significantly greater decrease in the powered secondary endpoint of LVESVi.



Decreased lung function and associated parameters in diabetic patients Diabetics were older, more likely to be men, overweight, have heart failure and less likely to be Caucasians and never smokers compared with patients without diabetes



Post hoc subgroup analysis on COMPARE trial: EES are superior to PES at two years in terms of safety and efficacy endpoints in treatment of MI A significant reduction in the primary endpoint, a composite of all-cause mortality, MI and TVR at two years was associated with EES.



The LODO-CRT trial: presence of left ventricular contractile reserve predicts a clinical and echocardiographic CRT response Independent predictors of CRT response identified on Multivariable analysis were left ventricular contractile reserve and interventricular dyssynchrony.



Statin use associated with a prostate-specific antigen level <10 ng/mL and a level >20 ng/mL The prostate-specific antigen level and National Comprehensive Cancer Network risk group were associated with statin and anticoagulants users on univariate analysis.



Postoperative atrial fibrillation is an independent predictor of operative mortality in patients undergoing a first isolated CABG A high protective effect for both operative mortality and long-term mortality was shown by the statin treatment in POAF patients after adjustment for potential confounders whereas it had no significant effect in patients without POAF.



Positive correlations between clot lysis time and PAI-1 antigen and thrombin-activatable fibrinolysis inhibitor activity 11% longer CLT (p=0.005) and 13% higher PAI-1 antigen (p=0.04) were reported by patients with in-stent thrombosis as compared to controls.



Dose-dependent statin use of 28 to 90, 91 to 365 and > 365 cumulative defined daily doses in reducing risk for hepato-cellular carcinoma Statin use and the risk of hepato-cellular carcinoma in the hepatitis B virus cohort showed a dose-response relationship.



The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF): More common paroxysmal atrial fibrillation in those with symptomatic atrial fibrillation More common symptomatic atrial fibrillation (EHRA Class ≥ 2) was reported in younger patients, especially in women, those with frailty, thyroid disease, obstructive sleep apnea, COPD, familial atrial fibrillation, sinus node dysfunction and heart failure.



Effects of low- and high-dose aspirin treatment on fibrin network formation in type 1 diabetics Significantly increased permeability coefficient was reported during treatment with 320 mg aspirin and a significant treatment effect was seen as compared with treatment with 75 mg aspirin.



Post hoc analysis of the Assessment of Pexelizumab in Acute Myocardial Infarction trial Higher 30 day readmission rates were reported for the United States than other countries. Shortest median length of stay was reported for US patients and longest for Germany



Angina/ congestive heart failure is a predictor of failure to respond to stenting Independent predictors of BP response to RAS were not hypertension urgency or emergency on Multivariate analysis. An independent predictor of failure to respond to RAS was angina/ congestive heart failure.



ONTARGET sub analysis: Safety and Efficacy of Low Blood Pressures among patients with diabetes Compared with nondiabetic patients, diabetic patients have a significantly higher risk for the primary endpoint, CV death, myocardial infarction, stroke and congestive heart failure hospitalization



Ability of various ARBs to decrease plasma advanced glycation end products levels in hypertensive patients on hemodialysis Olmesartan Medoxomil is associated with decreased plasma AGEs, pentosidine, and N-(Epsilon)-carboxymethyl-lysine levels in hemodialysis patients



Long term affect of probucol on survival after complete revascularization Probucol therapy improves long-term (>10-year) survival after complete revascularization



Effect of switching from other angiotensin II receptor blockers to Candesartan in patients with morning hypertension Target BPs (morning BPs ≤ 135/85 mm Hg and office BPs ≤ 140/90 mm Hg) achievement rates were 42.9% in the morning and 64.3% at office with candesartan



Understanding the inverse association between birth weight and hypertension for early identification of endothelial dysfunction individuals Significant association was found in between head circumference and hypertension during pregnancy on multivariable analysis



Results of the SUPERA SFA Registry study: 99% of procedures achieved procedure success with residual stenosis <30% Mean ABI increased and the mean Rutherford-Becker class decreased between baseline and 24 months



Suitability of Ross procedure in children with rheumatic fever and the risk factors associated Competing risks analysis in ten years after the Ross procedure displayed that 1% of patients died, 32% underwent autograft reoperation and 67% were alive and free from reoperation.



Circumferential shortening normalized by wall stress than longitudinal shortening identifies more patients with concealed left ventricular systolic dysfunction 46% of patients with HFpEF, 27% of patients with hypertension and 2% of controls were detected with isolated low stress-corrected mid-wall shortening.



Comparison of the incidence of subsequent vascular disease between treatment regimens by adding another oral glucose-lowering drug vs. starting insulin treatment After exclusions, 14, 904 people intensified treatment from one oral glucose-lowering drug, 7231 from two oral glucose-lowering drug and 978 from three oral glucose-lowering drug and started insulin (9, 41 and 90% respectively).



Interchangeable use of non-invasive techniques of inert gas rebreathing and impedance cardiography in determination of cardiac output Low operating costs are associated with both non-invasive techniques which only require a few expendable items for the rapid determination of cardiac function.



The PARTAGE study: prevalence of orthostatic hypotension and its association with blood pressure, arterial stiffness, cardiovascular and metabolic disorders and medication in individuals aged > 80 years living in nursing home A lower prevalence of orthostatic hypotension was reported in treated hypertensive patients with SBP ≤ 140mmHg than patients with SBP > 140mmHg.



Me-Can cohort study: An increased risk of high-grade glioma was found for diastolic blood pressure and triglycerides 1312 primary brain tumours diagnosed during follow-up were predominantly meningioma (n=348) and high-grade glioma (n=436).



Carotid Stenting in Patients at High Surgical Risk Thirty-day death/stroke/MI rate of 2.3% was obtained with carotid artery stenting in patients at high risk for surgery



Bivalirudin Better for STEMI in Real World Setting In-hospital mortality and bleeding is lower with bivalirudin vs. heparin plus GPI in primary PCI



Five year follow up results of Transplantation Of Progenitor Cells And Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) trial A persistent improvement of LV ejection fraction was documented in 31 patients on MRI subgroup analysis. Stable LV end-systolic volume remained but significant increase in LV end-diastolic volume was reported.



Direct correlation of soluble TWEAK levels with cardiac index, reduced 6-min walk test distances and peak oxygen consumption A cutoff value of 306 pg/ml for sTWEAK was revealed on ROC curve analysis of sTWEAK levels in pulmonary artery hypertension patients as an predictive of a reduced exercise capacity (6-min walk test <300 m) with a similar predictive value in patients with pulmonary artery hypertension.



Affect of lifestyle interventions on hypertension in women of reproductive age Most guidelines recommended hypertension screening at least every 2 years