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Reduced platelet reactivity achieved by an intensive glycemic control than with a conventional glycemic control in hyperglucemic type 2 diabetics suffering an acute coronary syndrome and carriers of the allele C of the rs956115 marker of Insulin Receptor Sustrate-1 gene Reduced ADP20µM, ADP5µM, collagen, epinephrine, TRAP, IRP, GPIIb/IIIa, P-selectin are reported by type 2 diabetics who were carriers of the C allele assigned to intensive glycemic control in comparison to those assigned to conventional glycemic control.



Effect of Statins on Late Target Lesion Revascularization After Sirolimus-Eluting Stent Implantation Risk for late TLR significantly favored statin use in patients implanted with sirolimus-eluting stents



Association of arterial stiffness with low-grade inflammation in type 1 diabetics without clinical cardiovascular disease Particularly in men with type 1 diabetes, low-grade inflammation is independently associated with arterial stiffness



An Isomaltulose diet than a sucrose diet lowers triglyceride levels but did not influence glycemic control in type 2 diabetes patients Significantly lower triglycerides were reported in the isomaltulose at 12 weeks when compared with the sucrose group. However, HbA1c at 12 weeks was significantly unaffected by isomaltulose.



Effect of antioxidant consumption on endothelial dysfunction in the elderly antioxidant, endothelial dysfunction, elderly



The Honolulu Asia Aging Study: Joint association of midlife BP and β-Amyloid levels with the risk for late-life Alzheimer disease and vascular dementia Elevated BP may compromise vascular integrity leading to cerebral amyloid angiopathy and impaired Aβ clearance from the brain



Analysis of the SOS Xience V Study: Use of Xience V Everolimus-eluting stent in saphenous vein grafts effectively suppresses neointima formation No thrombus was detected in the stented areas. The mean difference between the stent area and the lumen area was 0.36 ± 1.6 mm².



A risk factor for early death in children who undergo mitral valve replacement are low mitral valve annulus size and prosthesis/annulus mismatch Children aged < 18 yrs of age and with <10 kg weight required earlier re- mitral valve replacement since significantly better early freedom from re- mitral valve replacement (<6 years) was reported in those with >10 kg of weight.



Positive correlation between chylomicron lipopolysaccharide levels and the triglyceride increase after fat overload but not to degree of insulin resistance in morbidly obese patients A higher increase in lipopolysaccharide levels in serum and the chylomicron fraction after the fat overload were reported in the morbidly obese patients with the highest postprandial hypertriglyceridemia.



Relation between blood pressure and dementia in women followed for 37 years Association between blood pressure and dementia is complex and is influenced by antihypertensive treatment



Effect of fructose in isocaloric exchange for other carbohydrates on blood pressure There were no adverse effects of isocaloric substitution of fructose for other carbohydrates on blood pressure in humans



Safety of a percutaneous stent implantation demonstrated in most of the patients with coarctation by reducing the need for multiple anti-hypertensive drugs Notably, final stent diameter correlated with body surface area in medication free patients. Higher percentage of patients with transverse aorta/aorta diaphragm level >0.8 remained medication free than compared to those with < 0.8.



Contact impedance mapping using the Carto system helps differentiate focal from reentrant arrhythmias in patients undergoing electrophysiologic testing for long RP Supra-ventricular Tachycardias or SVT with variable AV conduction 25 patients diagnosed with macro reentrant atrial arrhythmias showed uniform impedance without a focal low area. It was also found that the focal area of low impedance either encompassed the site of successful focal ablation or was within 1.4±0.8 cm from atrial surface area.



Upper normal blood pressures can predict incident atrial fibrillation in healthy middle-aged men Sustained upper normal systolic BP is a significant predictor of subsequent AF.



Candesartan antihypertensive treatment influences the correlations in-between inflammatory markers that lead to low grade chronic inflammation and also improves antihypertensive capacity in type 2 diabetes patients Before candesartan administration, significant positive correlations were found between hs-CRP and MCP-1, IL-6 and MCP-1 and TTR and MCP-1 but these correlations were not found at the end of candesartan administration.



The EVOLVO Study: Remote monitoring as compared to standard follow-up with in-office visits and audible ICD alerts has an increased efficiency for an improved quality of care and reduces cardiac or device related events 23% reduction in rates of all hospital admissions for cardiac/ device-related events was reported in the remote arm vs. standardized patients' management arm. A more favorable change in Minnesota Living with Hearth Failure Questionnaire was observed in the remote arm till the 16-month.



Post hoc analysis of TRINITY study: Triple therapy of Olmesartan + Amlodipine and Hydrochlorothiazide is effective than the dual combination therapy for hypertensive patients with diabetes Greater mean reductions in systolic BP were achieved with triple therapy consisting of 40 mg Olmesartan + 10mg Amlodipine and 25 mg HCTZ than compared to the dual-combinations for both diabetes and non-diabetes patients with severe hypertension



LV muscarinic receptor density in remote and damaged regions of patients after myocardial infarction Higher B_max / LV muscarinic receptor density was reported in the remote regions of all patients after myocardial infarction than in the normal regions of controls. However, a reduced B_max was reported in the damaged regions, of both patient groups.



Transient dilation of the left ventricle on adenosine myocardial perfusion imaging is not related to chamber enlargement and myocardial stunning but is more likely a function of subendocardial hypoperfusion and impaired coronary flow reserve On myocardial perfusion imaging in the transient ischemic dilation group, a significant drop in LVEF, and an increase in both LVESV and LVEDV were observed between rest and early stress in patients undergoing single-day Tc-99m adenosine sestamibi myocardial perfusion imaging.



QUARTO Study: Best cardiac output obtained during pacing from a non-traditional vector unique to the quadripolar lead is greater than that obtained from a traditional vector Association of Bi-V pacing using vectors (only available with a quadripolar lead) with improved cardiac output was reported in 53% of patients.



Multi-scale entropy is a useful tool for heart failure detection and management in patients with systolic heart failure Significant correlation was shown by serum matrix metalloproteinase 2 levels with multi-scale entropy parameters such as Slope5, Area1-5, and Area6-15. Additionally, a strong and significant correlation existed especially between MMP-2 and Area6-15.



A feasible supraventricular tachyarrhythmias directed therapy like ventricular tachyarrhythmia's zone programming above 170/min can reduce inappropriate anti-tachycardia pacing and/or inappropriate shocks It was found that inappropriate therapies were triggered by atrial fibrillation with rapid ventricular response, non-atrial fibrillation supraventricular tachyarrhythmia's, abnormal sensing and sinus tachycardia.



Additional measurement of adiponectin level but not Brain natriuretic peptide levels are useful as a marker of heart failure in senile patients with body fat percent more than 40% or in between 40% to 50 % Heart failure presence was strongly correlated with an integral marker that was an increase of brain natriuretic peptide and adiponectin levels corrected by body fat percent levels. Patients with body fat percent in range 40-50% showed maximal strength of correlation.



Notch pathway dysregulation is underlying mechanism of dysfunction shown by the lipoaspirate mesenchymal stem cells from stromo-vascular fraction of the adipose tissue in heart failure patients Severe heart failure negatively affected the levels of senescence, stemness and differentiation capability of mesenchymal stem cells isolated from lipoaspirate.



Integrated effects of cardiovascular risk factors and left ventricular systolic dysfunction on myocardial blood flow and flow reserve in patients with angina-like chest pain and without significant coronary artery disease The only independent predictors of reduced myocardial flow reserve were the left ventricular ejection fraction and insulin resistance.



The moderate association between E/E'septal and pulmonary capillary wedge pressure in modern heart transplant recipients cautions the need for careful interpretation of an echocardiogram for the prediction of left ventricular filling pressure in modern heart transplant recipients with atrial anastomoses E/E' septal at a cut-off value of 22 could moderately identify a PCWP > 12 mm Hg in heart transplant patients with a sensitivity of 77 % and a specificity of 90 %.



Anterior myocardial infarction is an important risk factor influencing the global left ventricular contractility and the occurrence of heart failure in patients with coronary disease scheduled for elective coronary artery by-pass graft surgery Other than previous myocardial infarction (MI), similar results were observed between patients who did not have heart failure due to CAD and who had heart failure due to CAD for the preoperative therapy used, age, and the presence of risk factors for coronary disease.



An early detection of diastolic dysfunction in diabetics with subclinical diastolic dysfunction is possible with use of classic cardiovascular risk scores A Framingham>20% (62.5% sensitivity/SE, 76.9% specificity/SP) and a SCORE>2% (86.7%SE, 64%SP) is the best threshold for identifying diastolic dysfunction.



A lower blood pressure or SBP <90 mmHg leads to their worst prognosis only in heart failure patients with previous history of hypertension An occurrence of heart failure related mortality was reportedly associated with a crude hazard ratio of 2.208 [1.063-4.586] in those who had systolic blood pressure below 90 mmHg, when compared to the group that had SBP above 90 mmHg.



The Hepcidine link: Hepcidine levels in heart failure patients are related to inflammation and renal function Pearson correlation in iron deficiency subgroup could only demonstrate the correlation of hepcidine with M-Iron, LVEDV and creatinine. The only predictor for hepcidine levels was M-Iron.